In vitro chromosomal radiosensitivity in “chromosomal breakage syndromes”
نویسندگان
چکیده
منابع مشابه
Diagnosis of Fanconi Anemia: Chromosomal Breakage Analysis
Fanconi anemia (FA) is a rare inherited syndrome with diverse clinical symptoms including developmental defects, short stature, bone marrow failure, and a high risk of malignancies. Fifteen genetic subtypes have been distinguished so far. The mode of inheritance for all subtypes is autosomal recessive, except for FA-B, which is X-linked. Cells derived from FA patients are-by definition-hypersen...
متن کاملA chromosomal breakage syndrome with profound immunodeficiency.
The chromosomal breakage syndromes--ataxia-telangiectasia, Fanconi's anemia, and Bloom's syndrome--are associated with growth failure, neurologic abnormalities, immunodeficiency, and an increased incidence of malignancy. The relationship between these features is unknown. We recently evaluated a 21-year-old female with more severe chromosomal breakage, immunodeficiency, and growth failure than ...
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ژورنال
عنوان ژورنال: Cancer
سال: 1973
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(197308)32:2<380::aid-cncr2820320214>3.0.co;2-2